Research the development, evaluation and application of novel dynamic HIPEC protocols to help improving effectiveness of cancer therapy
Wat ga je doen?
The PhD student with a physics background will process and analyze biological and clinical HIPEC data (provided by another PhD student with a background in biology) in sophisticated mathematical models developed in an earlier project capable of integrating data on flow, temperature, chemotherapy concentration, temperature dependence of the effect of chemotherapy, temperature dependence of the penetration of chemotherapy into tissue for the different sequential low/high dose, low/high temperature 90 minute “step-up” heating protocols of mitomycin-C and platinum-based HIPEC applied in the different tumor models and in human clinical treatments.
Work will involve development, adaptation and application of advanced computer models simulating various aspects of the HIPEC procedure, which is novel in the field.
Wat neem je mee?
We are looking for a highly motivated candidate with a MSc degree in physics or a related background.
The candidate preferably has practical experience with mathematical and numerical models in computer simulations and advanced programming in C/C++.
The candidate should have good command of English.
Excellent analytical and communicative skills and the ability to work within a multidisciplinary research group are essential.
The research project should result in a PhD thesis.
Wat bieden we jou?
We offer ample opportunity for development, deepening and broadening, additional training and a place to grow! Working at Amsterdam UMC means working in an inspiring and professional environment where development is encouraged in every respect.
A jump start to your career in research work.
All te space for you to contribute shaping the care of tomorrow.
Working on large-scale and research project, with motivated colleagues from all over the world.
We offer a contract for a year (12 months) with the intention to be extended.
In addition to a good basic salary, we offer 8.3% end-of-year bonus and 8% holiday allowance.
Pension is accrued at Be Frank.
In addition to excellent accessibility by public transport, AMR also has a sufficient number of parking spaces for employees.
An active personnel association and the Young Amsterdam UMC association, both of which organise fun (sports) activities and events.
The candidate will work at the Department of Radiation Oncology of the Amsterdam University Medical centers, location AMC. The candidate will collaborate with biologists, physicists and clinicians working on HIPEC research at both locations of Amsterdam UMC.
The Amsterdam UMC and the PI’s for this project are widely acknowledged as leading experts in the field of clinical, pre-clinical and technical research on hyperthermia combined with radiotherapy or chemotherapy, as well as in the field of HIPEC. Colorectal cancer research is thriving at Amsterdam UMC and preclinical research results are readily translated into clinical practice.
Wat ga je onderzoeken?
Effective treatment of tumors metastasizing to the peritoneal cavity is a major challenge. Surgery followed by Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are applied to suppress macroscopic and microscopic peritoneal metastases, respectively, of cancers of different origins. During HIPEC a chemotherapy solution heated to 40-43°C is circulated through the peritoneum for 30 to 90 minutes. The elevated temperatures during HIPEC sensitize chemotherapy and thus improve the likelihood of tumour control. There is presently discussion on the optimal HIPEC protocol for peritoneal metastases of colorectal origin.
The four year multidisciplinary research project “Improving therapeutic effectiveness and reducing toxicity of HIPEC for colorectal peritoneal metastases (PMCRC) by applying “step-up” heating” is supported by a grant of the Dutch Cancer Society KWF and aims to optimize the clinical effectiveness of the HIPEC procedure by utilizing novel dynamic HIPEC protocols with sequential variation in dose, temperature level and duration of exposure to chemotherapy in in vitro, organoid, and in vivo tumor models. Finally clinical efficacy will be evaluated in a phase I clinical study. Goal is to establish HIPEC strategies resulting in more effective tumor eradication without unacceptable local and systemic side effects.
Two PhD positions are part of the project, both at the department of Radiation Oncology of the Academic Medical Center of the University of Amsterdam.
One PhD student has been hired to work at determining efficacy of sequential low/high dose, low/high temperature 90 minute “step-up” heating of mitomycin-C and platinum-based HIPEC drugs in organoid models of normal colorectal tissue and of relevant colorectal tumors, and in in vivo tumor models.
We now look for a second PhD student with a physics background who will process and analyze the data provided by the first PhD student with a background in biology for the different sequential low/high dose, low/high temperature 90 minute “step-up” heating protocols of mitomycin-C and platinum-based HIPEC applied in the different tumor models and in human clinical treatments.
A team of physicists, biologists and clinicians will advise on the work of both students.
During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.