BRAIN BARRIERS: Is blood-brain barrier malfunction the driving force of dementia?
Wat ga je doen?
Loss of the protective function of the blood-brain barrier (BBB) is an important contributor to dementia. Recent evidence from our consortium now shows that neurovascular impairment is one of the earliest events in dementia, but underlying mechanisms remain unknown. Deciphering which molecular pathways and altered (sub)cellular interactions induce such detrimental changes may uncover not only novel biomarkers for its dysfunction in patients, but also provide leads to innovative intervention strategies, already early in disease.
The successful candidate will uncover which changes at the level of the neurovasculature underlie dementia and decipher if identified pathways cause neurovascular dysfunction using a variety of unique human in vitro and animal models and patient material while applying high-dimensional single-cell techniques and high end microscopy.
Wat neem je mee?
We are looking for a highly driven, motivated and enthusiastic researcher with:
A master’s degree in a field related to biomedical sciences, neuroscience and/or immunology;
Affinity for vascular and neuroscience research;
Interest in high-dimensional technologies and pushing the boundaries of research through technology-driven applications;
Experience with in vitro models (iPSC based) and animal research is a plus;
You have a flexible, pro-active team spirit but you can also work independently;
Excellent communications skills in English, both written and verbal.
Willingness/openness to collaborate with (inter)national researchers.
Wat bieden we jou?
The position is for 4 years. We first offer a fixed term contract for 1 year, which under normal circumstances will be prolonged with 3 years. We also provide you with the opportunity to follow further training and development.
Salary scale OIO: € 2.631tot € 3.336 bruto with a 36 hour week (depending on qualifications and experience).
In addition to a good salary, we offer, among other things, 8.3% end-of-year bonus and 8% holiday allowance. Curious about what you will earn? Calculate your net salary here.
Free and unlimited access to the training offer of our online learning environment GoodHabitz
Your pension is accrued at ABP. Amsterdam UMC contributes 70% of this premium.
We reimburse 75% of your public transport travel costs and also offer a bicycle arrangement.
Waar ga je werken?
This project is part of the consortium BRAIN BARRIERS which focuses on the role of the neurovasculature in dementia, a collaboration between AUMC, LUMC, Maastricht UMC, Radboud UMC, and UMC Utrecht. The selected candidate will work together with various other PhD students in a unique research team which brings together experts with a drive for translational research, ranging from BBB biologists, preclinical scientists, imaging experts to clinicians.
At the Neuro-immunology research group at the Amsterdam UMC, you will work in a team with young and enthusiastic researchers, who have expertise in immunology, biochemistry, cell biology, neuroscience and neurological diseases. Research within the department Molecular Cell Biology and Immunology (VUmc) is performed in a stimulating environment and at an international high competitive level.
Wat ga je onderzoeken?
This project incorporates fundamental research questions as well as translational applications in in vitro and in vivo models and patient material. This project will be performed at the Neuro-immunology research group of prof. Elga de Vries in the Department of Molecular Cell Biology and Immunology (location VUmc; O|2 Lab Building) in collaboration with the Department of Biomedical Engineering and Physics (dr. Inge Mulder) at the Amsterdam UMC
The project is funded by a grant from Zon MW and is embedded in the Amsterdam Neuroscience research institute.
If you are interested in this job and you meet the requirements in the job profile, we encourage you to apply by sending a brief letter of introduction including motivation for this position, as well as your CV.
The preferred starting date for this position is February 1st 2023.
For more information about this position, you can contact prof.dr. Elga (HE) de Vries, via:contactinformatie.
For more information about the application procedure, you can contact Chey Edwards, corporate recruiter, via firstname.lastname@example.org or via 06-214 87 245.
A reference check can be part of the selection procedure. In addition, applying for a VOG (Certificate of Good Conduct) is mandatory for every new employee. The application for a VOG is started from Amsterdam UMC as soon as the new employee has been appointed. Read here more about the process.
Internal candidates are given priority over external candidates in the event of equal suitability.
Acquisition in response to this vacancy is not appreciated.