PhD candidate - human genetics and host-pathogen interactions of severe staphylococcal infections

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PhD candidate - human genetics and host-pathogen interactions of severe staphylococcal infections

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Vakgebied
Onderzoeker
Functie
PHd
Branche
Laboratorium
Aanstelling
Tijdelijk dienstverband
Plaatsingsdatum
16 september 2022
Niveau
WO
Ervaring
Ervaren
Dienstverband
Niet nader bepaald

The department of Medical Microbiology offers an exciting position as a PhD candidate on studying the human genetics and host-pathogen interactions of severe staphylococcal infections.

Dit ga je doen

Staphylococcus aureus is a bacterium that causes superficial infections in most humans. Unexpectedly and tragically, some previously healthy individuals develop a life-threatening disease upon infection. What explains the tremendous variability between humans in the severity of their infection with S. aureus? Most cases of severe disease remain unexplained, but recent discoveries indicate that specific human genetic defects, known as inborn errors of immunity, increase an individual’s susceptibility to staphylococcal virulence factors. The discovery of inborn errors of immunity serves as a compass for the clarification of staphylococcal host-pathogen interactions. A deep understanding of these interactions, in turn, can contribute to the development of innovative therapeutics.

You will investigate if the severe staphylococcal infections in a cohort of previously healthy patients are explained by inborn errors of their immunity to S. aureus. You will perform state-of-the art analyses to identify new human genetic etiologies of severe staphylococcal disease. You will validate your genetic discoveries experimentally, including with cells from patients. You will dissect the mechanisms of severe staphylococcal disease at the molecular, cellular, tissue, immunological, and whole-organismal level. By learning from experiments of Nature, you will directly link staphylococcal virulence factors with human genetic predispositions to infection. You will participate in a multidisciplinary team and present your work during internal meetings and (international) conferences.

Hier ga je werken

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Dit neem je mee

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PhD candidate - human genetics and host-pathogen interactions of severe staphylococcal infections

Utrecht
WO
Niet nader bepaald
Tijdelijk dienstverband
Nu solliciteren