PhD Developing Clinically Applicable Gene Therapies for Cardiac Arrhythmias

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PhD Developing Clinically Applicable Gene Therapies for Cardiac Arrhythmias

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Vakgebied
Onderzoeker
Functie
PHd
Branche
Ziekenhuis
Aanstelling
Tijdelijk dienstverband
Plaatsingsdatum
19 november 2022
Niveau
WO
Ervaring
Ervaren
Dienstverband
Niet nader bepaald

Intro

Are you eager to to expedite the field of cardiac gene therapy? Then please apply for this PhD trajectory and convince us that you have the needed skills to make difference.

Wat ga je doen?

Within this project, your main initial tasks will be to construct adeno-associated virus (AAV) and non-viral vectors and validate these in various in vitro and intact animal models.

In the first 1-2 years you will participate in on going studies that are carried out by PhD students in their final year(s) of PhD training. In the second half of your PhD trajectory you will get the opportunity to start new projects that you can (partially) design yourself. In the performance of these tasks you will receive technical support of your team members and guidance from the project leaders.

In addition, you will be writing at least four papers for publication in reputed peer-reviewed international scientific journals and present your progress at (international) scientific conferences.

Wat neem je mee?

We seek a highly motivated scientist who enjoys an interdisciplinary environment!

  • Candidates should have a Master’s degree in a life science subject.
  • Preferably work experience with gene therapy engineering and culture of primary cells or derivatives from (pluripotent) stem cells.
  • An excellent higher education track record and strong scientific curiosity.
  • Fluent spoken and written English skills are required.
  • You are able to work independently but also as part of a team, and need good communication skills.

Wat bieden we jou?

  • A contract for 12 months in accordance with the CAO UMC 2022-2023, with the possibility of extension.
  • Salary scale 10: 3047,- to 4800 euro gross for full-time employment (depending on education and experience).
  • Besides a good basic salary, you will also receive 8.3% end-of-year bonus and 8% holiday allowance. Calculate your net salary here.
  • A flying start to your career in research work in a metropolis with a diverse and open culture, and a multicultural society.
  • Plenty of room for your drive to shape tomorrow's healthcare.
  • Working on large-scale and in-house research, with motivated colleagues from all corners of the world.
  • Pension accrual with BeFrank, a modern, comprehensible and fairly priced pension.
  • Excellent accessibility by public transport and reimbursement of a large part of your travel expenses. We also have sufficient parking spaces at the AMC location and a good bicycle scheme.

View all terms of employment at AMR  Arbeidsvoorwaarden AMR - Amsterdam UMC

 

Waar ga je werken?

You will be working in the Boink group (Boink group – Medical Biology – AMC (medischebiologie.nl)) that is embedded in the department of Medical Biology (headed by Prof. Vincent Christoffels).

Our group is further associated with the department of Clinical Cardiology (headed by Prof. Steven Chamuleau) and Amsterdam Cardiovascular Sciences (www.amsterdamumc.org/en/research/institutes/amsterdam-cardiovascular-sciences.htm), jointly representing one of the largest cardiovascular research institutes in the Netherlands.

Wat ga je onderzoeken?

Electronic pacemakers constitute the present state-of-the-art treatment for patients with disease-causing failure of impulse formation and/or impulse propagation in the heart. Although these devices have greatly improved the care of patients with sinus node dysfunction, acquired atrioventricular block and specific types of fascicular block, electronic pacemakers have a number of shortcomings and may cause serious complications.

Accordingly, there is a clear demand for alternative approaches to treat the aforementioned heart rhythm disorders. It is therefore our ambition to develop clinically-applicable gene therapy-based pacemakers (“biological pacemakers”) that carry to potential to circumvent the major shortcomings associated with electronic pacemakers. Moreover, our work on these biological pacemakers allows us to develop and optimize platform technologies that carry the potential to transform the field of cardiac gene therapy.

This research project is supported by our start-up company PacingCure (www.PacingCure.com) and an European Innovation Council (EIC) Transition grant.

 

The first round of interviews is scheduled for 15-11-2022. We ask you to take this into account in advance. The second round of interviews will in principle follow 29-11-2022. 

Do you have any questions? For substantive information, please contact Dr Geert Boink, Cardiologist, at g.j.boink@amsterdamumc.nl.

For more information about the application procedure, please contact Tanja Hart, Recruitment Advisor, via t.hart@amsterdamumc.nl or via 06-21603178.

A reference check and screening may be part of the procedure. Read here what this entails. If you join us, we will ask for a VOG (Certificate of Good Conduct). 

Acquisition in response to this vacancy is not appreciated.

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PhD Developing Clinically Applicable Gene Therapies for Cardiac Arrhythmias

Amsterdam
WO
Niet nader bepaald
Tijdelijk dienstverband
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