Analist EXPIRE lab

Job description

As an analyst you will work within the Pathology & Medical Biology (PMB) department of the University Medical Center Groningen, laboratory Experimental Lung Diseases and Inflammation Research (EXPIRE). Within PMB, several renowned research groups work on damage and repair processes in pathophysiological processes, using translational and multi-omics approaches (transcriptomics, for example single cell RNA sequencing, proteomics, etc.) and advanced cellular and molecular techniques. You will gain insight into the mechanisms and new therapeutic strategies for chronic inflammatory diseases.

EXPIRE group

The EXPIRE group consists of 30-35 researchers, including PhD students, analysts, postdocs and master/bachelor students. You will work closely with other analysts as well as doctors and nurses from the Pulmonology department. Within the Pulmonary Diseases department there is an extensive fundamental, patient-oriented line of research into the development, progression and treatment of lung diseases.
The research is embedded within the Groningen Research Institute of Asthma and COPD, a multidisciplinary and translational research institute. The analyst will play a central role in conducting biomedical research, with a focus on the lung disease COPD (chronic obstructive pulmonary disease). The research has a highly translational approach with the associated processing and analysis of patient-derived samples. The analyst collects the material from doctors in the operating room, processes and stores the samples, and is involved in the culture of cells from the patient. The analyst is also responsible for the administration and registration of all samples. As an analyst, you must be prepared to proactively participate in general laboratory management tasks, such as ISO regulatory matters, and to work closely with the clinic.

You will be involved in processing patient material, facilitating research and developing and implementing new technologies within a large, national consortium project: Precision Medicine for More Oxygen (P4O2). Patient material will come from a cohort of COPD and control subjects from the SHERLOCk project (An integrative genomic approach to Solve the puzzle of severe early-Onset COPD). As an analyst you are responsible for collecting, storing and managing all clinical samples collected within the COPD cohort, processing the samples for (single cell) RNA sequencing and proteomics analyses, isolating cells and culturing these cells in different models (air-liquid interface cultures, organoid mini-lungs). Furthermore, you will contribute to setting up a new in vitro airway-on-chip model to study the interaction of structural lung cells with the exposome (inhaled substances from the environment) in a 3D setting.

What do we need

• HBO or higher education level (preferably biomedical).
• You can work independently but also function well in a dynamic team.
• You have expertise in isolation of human cells (such as PBMCs) and tissue culture, preferably primary human (lung epithelial) cell culture models and you have a VMT certificate.
• You have an affinity with 'omics' technology such as transcriptomics (RNA sequencing), proteomics or epigenetics.
• You have experience with immunological, microbiological and cell and molecular biology techniques such as DNA and RNA isolation, qPCR or cDNA libraries, FACS (multicolor and sorting), ELISA, cloning, immunohistochemistry, immunofluorescence microscopy.
• You are able to independently perform analyzes (experience with Excel, graphpad prism, etc.) and report on the data.
• You have excellent organizational, communication and interaction skills.
• You have good project and time management skills.
• You are flexible in terms of working hours and can speak and write in English language.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.

What do we offer

This is a full-time appointment (36 hours), for a year with the prospect of extension.Your salary will be a maximum of € 4.214,- gross per month (scale 7M), depending on your qualifications and relevant experience, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. and a job-related budget for further training. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

A look in the department:
You are welcome for a tour and further introductions, even if you do not want to write an application letter immediately. You can make an appointment for this with one of the contact persons below.

For questions about the position

Any questions? Do contact us.

How to apply

Please use the the digital application form at the bottom of this page - only these will be processed. You can apply until 5 May 2024.
Within half an hour after sending the digital application form you will receive an email- confirmation with further information.

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